Immunodeficiency Testing

• Severe Combined Immunodeficiency (SCID): Testing reveals the absence of functional immune cells, guiding immediate interventions like bone marrow transplantation, enzyme replacement, or gene therapy to restore immune function.​

• Common Variable Immunodeficiency (CVID): By detecting low immunoglobulin levels, testing enables the prescription of immunoglobulin replacement therapy, boosting the immune system and preventing infections.

•  X-linked Agammaglobulinemia (XLA): Testing identifies low or absent B-cells, leading to regular immunoglobulin infusions and antibiotic prophylaxis to safeguard against infections.

• Hyper IgM Syndrome: Identifying abnormal antibody production directs the use of immunoglobulin replacement therapy and possibly hematopoietic stem cell transplantation to enhance immune defense.

• Selective IgA Deficiency: Testing for low IgA levels helps manage infections with targeted antibiotics and informs patients about transfusion risks.

• HIV/AIDS: Testing confirms the diagnosis and monitors immune function, guiding antiretroviral therapy to manage the disease and prevent opportunistic infections.

• Malnutrition-related immune deficiencies: Testing uncovers immune deficiencies, allowing providers to address nutritional gaps with dietary interventions and supplements.

• Immune suppression due to chemotherapy or radiation therapy: Testing monitors immune function during treatment, enabling adjustments in therapy and the use of growth factors or prophylactic antibiotics to minimize infection risk.

• Chronic infections (e.g., tuberculosis, hepatitis): Testing reveals immune suppression, guiding treatment with targeted antibiotics or antiviral therapies while monitoring immune recovery.

• Cancers affecting the immune system (e.g., leukemia, lymphoma): Testing identifies immune deficits that can be addressed with targeted therapies, immunotherapy, or bone marrow transplantation.

• Lupus, Rheumatoid Arthritis, Multiple Sclerosis, Type 1 Diabetes: Testing identifies immune dysregulation, guiding the use of immunosuppressive drugs, biologics, and other therapies to control disease activity and prevent organ damage.

Frequent respiratory, ear, skin, and fungal infections: Testing uncovers underlying immunodeficiency, leading to targeted treatment with antibiotics, antifungals, or prophylactic therapy to prevent recurrent infections.

• Severe allergic reactions (anaphylaxis): Testing identifies immune abnormalities, guiding the use of allergy desensitization therapies and emergency management plans to prevent life-threatening reactions.

• Chronic allergies or asthma: Testing reveals immune dysfunction, allowing providers to tailor immunotherapy or other interventions to better control symptoms and reduce flare-ups.

• Inflammatory Bowel Disease (IBD): Testing differentiates between immune-mediated inflammation and other causes, guiding the use of immunosuppressive drugs, biologics, or targeted therapies.

• Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): Testing confirms immune-mediated nerve damage, leading to treatment with immunotherapy, plasmapheresis, or other interventions.

• Monitoring after organ or bone marrow transplantation: Testing detects early signs of rejection or infection, allowing for adjustments in immunosuppressive therapy and preventive measures.

• DiGeorge Syndrome (22q11.2 deletion syndrome): Testing identifies immune deficits, guiding interventions like thymus transplantation, immunoglobulin replacement, and close monitoring.

• Wiskott-Aldrich Syndrome: Testing reveals immune and platelet abnormalities, leading to treatment with immunoglobulin replacement, antibiotics, and possibly bone marrow transplantation.

• Ataxia-Telangiectasia: Testing detects immune dysfunction, enabling preventive care and monitoring for associated cancers or lung disease.

• To rule out immune dysfunction: Testing can determine if immune deficiencies contribute to fatigue, guiding the use of immunomodulatory treatments or supportive therapies.

• Persistent, unexplained infections or health issues: Testing uncovers hidden immune deficiencies, leading to targeted therapies like immunoglobulin replacement or antibiotics to resolve chronic health problems.